The objective of this chapter is to provide clinicians with a clinical model of hEDS and HSD for which treatment can be optimized to the needs of the individual patient. Due to the complexity of the symptom profiles of HSD/hEDS, the international classification of functioning (ICF) will be adopted as a central framework. The ICF is a multidimensional model of functioning with activities and participation as the key construct. This model provides a framework to describe limitations associated with an individual’s functioning and identifies influencing environmental factors. On this framework a clinical profile and treatment strategy can be based.